The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 19, 2008
Filed:
Mar. 14, 2003
Lola M. Reid, Chapel Hill, NC (US);
Nicholas Moss, Carrboro, NC (US);
Mark Furth, Chapel Hill, NC (US);
John W. Ludlow, Carrboro, NC (US);
Andrew T. Bruce, Holly Springs, NC (US);
Lola M. Reid, Chapel Hill, NC (US);
Nicholas Moss, Carrboro, NC (US);
Mark Furth, Chapel Hill, NC (US);
John W. Ludlow, Carrboro, NC (US);
Andrew T. Bruce, Holly Springs, NC (US);
University of North Carolina at Chapel Hill, Chapel Hill, NC (US);
Vesta Therapeutics, Inc., Bethesda, MD (US);
Abstract
Hepatic progenitors comprise two populations of human hepatic stem cells, primitive and proximal hepatic stem cells, and two populations of committed progenitors, one for biliary cells and one for hepatocytes. Human primitive hepatic stem cells are a very small fraction of the liver cell population and give rise to proximal hepatic stem cells constituting a much larger fraction of the liver. Human proximal hepatic stem cells give rise to biliary and hepatocyte committed progenitors. Primitive and proximal stem cells are the primary stem cells for the human liver. Human primitive hepatic stem cells may be isolated by immunoselection from human livers or culturing human liver cells under conditions which select for a human primitive hepatic stem cell. Proximal hepatic stem cells may be isolated by immunoselection, or by culturing human liver cells under conditions which include a developmental factor. Proximal hepatic stem cells may also be isolated by culturing colonies comprising a primitive hepatic stem cell under conditions which include a developmental factor. Resulting compositions may be used for treating liver disorders and for producing bioartificial organs.