The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 19, 2008
Filed:
Jul. 31, 2002
Robert Charles Ladner, Ijamsville, MD (US);
Sonia Kosow Guterman, Belmont, MA (US);
Bruce Lindsay Roberts, Southborough, MA (US);
William Markland, Southborough, MA (US);
Arthur Charles Ley, Newton, MA (US);
Rachel Baribault Kent, Boxborough, MA (US);
Robert Charles Ladner, Ijamsville, MD (US);
Sonia Kosow Guterman, Belmont, MA (US);
Bruce Lindsay Roberts, Southborough, MA (US);
William Markland, Southborough, MA (US);
Arthur Charles Ley, Newton, MA (US);
Rachel Baribault Kent, Boxborough, MA (US);
Dyax Corp., Cambridge, MA (US);
Abstract
The invention relates, in part, to a library of chimeric proteins, each chimeric protein including a mini-protein between about eight and about forty amino acids long, wherein the mini-protein has a single disulfide bond formed by a pair of invariant cysteines and has only two cysteines. The chimeric protein also includes at least a portion of an outer surface protein of a genetic package, wherein the chimeric protein is displayed on the outer surface of the genetic package. The invention also includes, in part, a mixture of nucleic acids that encode a library of the invention. The invention also includes, in part, a process for identifying proteins with a desired binding activity against a target, the process including screening a library of chimeric proteins of the invention; and identifying the chimeric protein. The invention, in part, also includes chimeric proteins expressed by a library of the invention.