The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 12, 2008
Filed:
Aug. 31, 2004
Meng Hsin Chen, Westfield, NJ (US);
James B. Doherty, Montvale, NJ (US);
Luping Liu, Plainsboro, NJ (US);
Swaminathan Natarajan, Scotch Plains, NJ (US);
Robert M. Tynebor, Woodbridge, NJ (US);
Meng Hsin Chen, Westfield, NJ (US);
James B. Doherty, Montvale, NJ (US);
Luping Liu, Plainsboro, NJ (US);
Swaminathan Natarajan, Scotch Plains, NJ (US);
Robert M. Tynebor, Woodbridge, NJ (US);
Merck & Co. Inc., Rahway, NJ (US);
Abstract
This invention relates to potent potassium channel blocker compounds of Formula (I) or a formulation thereof for the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans, or a pharmaceutically acceptable salt, in vivo hydrolysable ester, enantiomer, diastereomer or mixture thereof: formula (II) represents Caryl or Cheterocyclyl, said aryl or heterocyclyl optionally substituted with 1-3 groups selected from R; Z represents (CH)PO(OR)(OR*).