Heterocyclic compounds

Abstract

This invention features a compound of formula (I): Ris aryl or heteroaryl; each of Rand R, independently, is H, halogen, CN, alkyl, OR, or NRR; Ris H, halogen, CN, alkyl, alkenyl, alkynyl, aryl, heteroaryl, cyclyl, heterocyclyl, OR, OC(O)R, OC(O)NRR, NRR, NRC(O)R, NRS(O)RNRS(O)R, NRC(O)NRR, NRC(S)NRR, NRC(NR)NRR, NRC(O)OR, S(O)NRR, S(O)NRR, S(O)R, S(O)R, C(O)R, C(O)OR, or C(O)NRR; Ris H or alkyl; n is 0, 1, 2, 3, 4, 5, or 6; A is O, S, S(O), S(O), or NR; B is N or CR; X is O, S, S(O), S(O), NR, or C(O); Y is a covalent bond, C(O), C═NR, O, S, S(O), S(O), or NR; Z is N or CH; each of U and V, independently, is N or CR; and W is O, S, or NR; in which each of R, R, R, and R, independently, is H, alkyl, aryl, heteroaryl, cyclyl, or heterocyclyl; Ris H, alkyl, aryl, acyl, or sufonyl; and Ris H, alkyl, aryl, acyl, sulfonyl, alkoxyl, amino, ester, amide, CN, or halogen. The compound is useful for treating an interleukin-12 overproduction-related disorder.