The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 12, 2008
Filed:
Jun. 18, 2004
Grayson B. Lipford, Watertown, MA (US);
Alexandra Forsbach, Ratingen, DE;
Charles Zepp, Hardwick, MA (US);
Grayson B. Lipford, Watertown, MA (US);
Alexandra Forsbach, Ratingen, DE;
Charles Zepp, Hardwick, MA (US);
Coley Pharmaceutical Group, Inc., Wellesley, MA (US);
Coley Pharmaceutical GmbH, Langenfeld, DE;
Abstract
The invention provides methods and compositions useful for modulating signaling through Toll-like receptors. The methods involve contacting a TLR-expressing cell with a small molecule having a core structure including at least two rings. Certain of the compounds are 4-primary amino quinolines. Many of the compounds and methods are useful specifically for inhibiting immune stimulation involving at least one of TLR9, TLR8, TLR7, and TLR3. The methods may have use in the treatment of autoimmunity, inflammation, allergy, asthma, graft rejection, graft versus host disease, infection, sepsis, cancer, and immunodeficiency.