The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 12, 2008
Filed:
Dec. 04, 1998
Veronique M. Braud, Oxford, GB;
David S. J. Allan, Oxford, GB;
Graham S. Ogg, Oxford, GB;
Christopher A. O'callaghan, Pasadena, CA (US);
Andrew J. Mcmichael, Beckley, GB;
Veronique M. Braud, Oxford, GB;
David S. J. Allan, Oxford, GB;
Graham S. Ogg, Oxford, GB;
Christopher A. O'Callaghan, Pasadena, CA (US);
Andrew J. McMichael, Beckley, GB;
Isis Innovation Limited, Oxford, GB;
Abstract
The invention relates to a method of testing a compound for biological activity, which method comprises providing cells expressing one of the CD94/NKG2 family of receptors, contacting the cells with recombinant HLA-E under binding conditions in the presence of the test compound, and determining whether the presence of the compound affects the binding of HLA-E to the cells. The HLA-E property of binding to CD94/NKG2 receptors on NK cells and a subset of CD8+ T cells is useful for targeting CD94/NKG2+ cells for a variety of purposes such as identification, isolation, killing or inactivation.