The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 05, 2008
Filed:
Mar. 29, 2007
Kenneth M. Boy, Durham, CT (US);
Shirong Zhu, Cheshire, CT (US);
John E. Macor, Guilford, CT (US);
Shuhao Shi, Madison, CT (US);
Samuel Gerritz, Guilford, CT (US);
Kenneth M. Boy, Durham, CT (US);
Shirong Zhu, Cheshire, CT (US);
John E. Macor, Guilford, CT (US);
Shuhao Shi, Madison, CT (US);
Samuel Gerritz, Guilford, CT (US);
Bristol-Myers Squibb Company, Princeton, NJ (US);
Abstract
There is provided a series of substituted N-aryl pyrrolidine derivatives of Formula (I) or a stereoisomer; or a pharmaceutically acceptable salt thereof, wherein R, R, R, R, R, R, R, R, and p as defined herein, their pharmaceutical compositions and methods of use. These compounds inhibit the processing of amyloid precursor protein (APP) by β-secretase and, more specifically, inhibit the production of Aβ-peptide. The present disclosure is directed to compounds useful in the treatment of neurological disorders related to β-amyloid production, such as Alzheimer's disease and other conditions affected by anti-amyloid activity.