The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 05, 2008
Filed:
Aug. 17, 2000
Eva-maria Mandelkow, Hamburg, DE;
Eckhard Mandelkow, Hamburg, DE;
Birgit Lichtenberg-kraag, Bärenklau, DE;
Jacek Biernat, Hamburg, DE;
Gerard Drewes, Hamburg, DE;
Barbara Steiner, Ludwigshafen, DE;
Eva-Maria Mandelkow, Hamburg, DE;
Eckhard Mandelkow, Hamburg, DE;
Birgit Lichtenberg-Kraag, Bärenklau, DE;
Jacek Biernat, Hamburg, DE;
Gerard Drewes, Hamburg, DE;
Barbara Steiner, Ludwigshafen, DE;
Abstract
The invention relates to epitopes of the tau protein which are specifically occurring in a phosphorylated state in tau protein from Alzheimer paired helical filaments, to protein kinases which are responsible for the phosphorylation of the amino acids of the tau protein giving rise to said epitopes, and to antibodies specific for said epitopes. The invention further relates to pharmaceutical compositions for the treatment or prevention of Alzheimer's disease, to diagnostic compositions and methods for the detection of Alzheimer's disease and to the use of said epitopes for the generation of antibodies specifically detecting Alzheimer tau protein. Additionally, the invention relates to methods for testing drugs effective in dissolving Alzheimer paired helical filaments or preventing the formation thereof.