The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 05, 2008
Filed:
Jan. 17, 2006
Applicants:
Takumi Kawabe, Numazu, JP;
Hidetaka Kobayashi, Numazu, JP;
Inventors:
Takumi Kawabe, Numazu, JP;
Hidetaka Kobayashi, Numazu, JP;
Assignee:
Canbas Co., Ltd., Numazu, Shizuoka, JP;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/21 (2006.01); A61K 31/235 (2006.01); A61K 31/495 (2006.01); A61K 31/497 (2006.01); A61K 31/535 (2006.01); A61K 31/5375 (2006.01);
U.S. Cl.
CPC ...
Abstract
The invention provides compositions and methods to inhibit the cell cycle G2 checkpoint, in particular the DNA-damage-induced G2 checkpoint, in mammalian cells including human cells. Specifically, the invention provides compositions and methods to sensitize cells to DNA-damaging agents by abrogating the cell cycle G2 checkpoint. Compounds of the invention are used to treat proliferative disorders such as cancer. The invention provides compositions and methods for selectively sensitizing G1 checkpoint impaired cancer cells to DNA-damaging agents and treatments.