The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 05, 2008
Filed:
Mar. 08, 2007
Dominique Lesuisse, Montreuil, FR;
Gilles Dutruc-rosset, Paris, FR;
Franck Halley, Sevres, FR;
Didier Babin, Montigny, FR;
Thomas Rooney, Orsay, FR;
Gilles Tiraboschi, Chevilly Larue, FR;
Dominique Lesuisse, Montreuil, FR;
Gilles Dutruc-Rosset, Paris, FR;
Franck Halley, Sevres, FR;
Didier Babin, Montigny, FR;
Thomas Rooney, Orsay, FR;
Gilles Tiraboschi, Chevilly Larue, FR;
Aventis Pharma S.A., Anthony, FR;
Abstract
The present invention relates to the use of novel derivatives of general formula (I) in whichR3 is a (1-6C)alkyl, aryl, aryl(1-6C)alkyl, heteroaryl, heteroaryl(1-6C)alkyl, aryl or heteroaryl fused to a (1-10C) cycloalkyl, heterocycle, heterocycloalkyl, cycloalkyl, adamantyl, polycycloalkyl, alkenyl, alkynyl, CONR1R2, COOR1, SOR1, C(═NH)R1 or C(═NH)NR1 radical;R5, R6 and R7 are, independently of one another, chosen from the following radicals: halogen, CN, NO, NH, OH, OR8, COOH, C(O)OR8, —O—C(O)R8, NR8R9, NHC(O)R8, C(O)NR8R9, NHC(S)R8, C(S)NR8R9, SR8, S(O)R8, SOR8, NHSOR8, SONR8R9, —O—SOR8, —SO—O—R8, trifluoromethyl, trifluoromethoxy, (1-6C)alkyl, (1-6C)alkoxy, aryl, aryl(1-6C)alkyl, heteroaryl, heteroaryl(1-6C)alkyl, heterocycle, cycloalkyl, alkenyl, alkynyl, adamantyl or polycycloalkyl, to treat a disease selected from the group consisting of: neurodegenerative diseases, strokes, cranial and spinal traumas and peripheral neuropathies, obesity, metabolic diseases, type II diabetes, essential hypertension, atherosclerotic cardiovascular diseases, polycystic ovaries syndrome, syndrome X, immunodeficiency and cancer.