The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 05, 2008
Filed:
Aug. 10, 1998
Ulrich Klar, Berlin, DE;
Wolfgang Schwede, Berlin, DE;
Werner Skuballa, Berlin, DE;
Bernd Buchmann, Neuendorr, DE;
Ulrich Klar, Berlin, DE;
Wolfgang Schwede, Berlin, DE;
Werner Skuballa, Berlin, DE;
Bernd Buchmann, Neuendorr, DE;
Bayer Schering Pharma AG, Berlin, DE;
Abstract
This invention relates to the new epothilone derivatives of general formula I, in which substituents Y, Z, R, R, R, R, R, D-E, R, R, R, Rand X have the meanings that are indicated in more detail in the description. The new compounds interact with tubulin by stabilizing microtubuli that are formed. They are able to influence the cell-splitting in a phase-specific manner and are suitable for treating malignant tumors, for example, ovarian, stomach, colon, adeno-, breast, lung, head and neck carcinomas, malignant melanomas, acute lymphocytic and myelocytic leukemia. In addition, they are suitable for anti-angiogenesis therapy as well as for treatment of chronic inflammatory diseases (psoriasis, arthritis). To avoid uncontrolled proliferation of cells and for better compatibility of medical implants, they can be applied or introduced into polymer materials. The compounds according to the invention can be used alone or to achieve additive or synergistic actions in combination with other principles and classes of substances that can be used in tumor therapy.