Respiratory syncytial virus replication inhibitors

Abstract

The present invention concerns compounds of formula (I), prodrugs, N-oxides, addition salts, quaternary amines, metal complexes and stereochemically isomeric forms thereof wherein -a=a-a=a- represents a radical of formula —CH═CH—CH═CH—; —N═CH—CH═CH—; —CH═N—CH═CH—; —CH═CH—N═CH—; CH═CH—CH═N—; wherein each hydrogen atom may optionally be substituted; Q is a radical of formulae (b-1), (b-2), (b-3), (b-4), (b-5), (b-6), (b-7) and (b-8), wherein Alk is Calkanediyl; Yis a bivalent radical of formula —NR— or —CH(NRR); Xis NR, S, S(═O), S(═O), O, CH, C(═O), CH(═CH), CH(OH), CH(CH), CH(OCH), CH(SCH), CH(NRR), CH—NRor NR—CH; Xis a direct bond, CH, C(═O), NR, Calkyl-NR, NR—Calkyl, t is 2 to 5; u is 1 to 5; v is 2 or 3; and whereby each hydrogen in Alk and in (b-3), (b-4), (b-5), (b-6), (b-7) and (b-8), may optionally be replaced by R; provided that when Ris hydroxy or Calkyloxy, then Rcannot replace a hydrogen atom in the α position relative to a nitrogen atom; G is a direct bond or optionally substituted Calkanediyl; Ris an optionally substituted bicyclic heterocycle; Ris hydrogen, formyl, Calkylcarbonyl, Hetcarbonyl, pyrrolidinyl, piperidinyl, homopiperidinyl, Ccycloalkyl or Calkyl substituted with N(R)and optionally with another substituent; Ris hydrogen, hydroxy, Calkyl, Calkyloxy, arylCalkyl or arylCalkyloxy, Ris hydrogen, Calkyl or arylCalkyl; R, R, Rand Rare hydrogen or Calkyl; or Rand R, or Rand Rtaken together from a bivalent radical of formula —(CH)— wherein S is 4 or 5; Ris hydrogen, Calkyl, formyl, hydroxyCalkyl, Calkylcarbonyl or Calkyloxycarbonyl; aryl is optionally substituted phenyl; Het is pyridyl, pyrimidinyl, pyryzinyl, pyridazinyl; as respiratory syncytial virus replication inhibitors; their preparation, compositions containing them and their use as a medicine.