The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 05, 2008
Filed:
Aug. 23, 2004
Mark A. Olson, Middletown, MD (US);
Charles B. Millard, Frederick, MD (US);
Michael P. Byrne, New Market, MD (US);
Robert W. Wannemacher, Frederick, MD (US);
Mark A. Olson, Middletown, MD (US);
Charles B. Millard, Frederick, MD (US);
Michael P. Byrne, New Market, MD (US);
Robert W. Wannemacher, Frederick, MD (US);
The United States of America as represented by the Secretary of the Army, Washington, DC (US);
Abstract
Disclosed herein are polypeptides and variants thereof comprising a polypeptide sequence having substantial identity to ricin A chain (RTA) that lack detectable N-glycosidase-rRNA activity or exhibit reduced N-glycosidase-rRNA activity as compared to controls and methods of making and using thereof. The polypeptides and variants have a greater solubility in aqueous solutions of physiological pH and ionic strength than RTA and also retain the integrity of the neutralizing immunological epitope of wild type RTA. Also disclosed are immunogenic compositions that may be used to immunize a subject against ricin intoxication. Methods of immunizing against, treating, and preventing ricin intoxication are disclosed.