The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 05, 2008
Filed:
May. 03, 2004
Applicants:
Robert A. Lazarus, Millbrae, CA (US);
Clark Qun Pan, San Francisco, CA (US);
Inventors:
Robert A. Lazarus, Millbrae, CA (US);
Clark Qun Pan, San Francisco, CA (US);
Assignee:
Genentech, Inc., South San Francisco, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 9/16 (2006.01); C12N 9/14 (2006.01); C12N 9/00 (2006.01); C07K 14/00 (2006.01); A61K 38/46 (2006.01); C12P 21/00 (2006.01); C12Q 1/44 (2006.01); C12Q 1/00 (2006.01); C12Q 1/68 (2006.01); C12N 15/00 (2006.01); C12N 5/10 (2006.01); C12N 1/21 (2006.01); C07H 21/00 (2006.01);
U.S. Cl.
CPC ...
Abstract
The present invention relates to amino acid sequence variants of human DNase I that have increased DNA-hydrolytic activity. The invention provides nucleic acid sequences encoding such hyperactive variants, thereby enabling the production of these variants in quantities sufficient for clinical use. The invention also relates to pharmaceutical compositions and therapeutic uses of hyperactive-variants of human DNase I.