The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 29, 2008
Filed:
Sep. 16, 2004
Rolf Gericke, Seeheim-Jugenheim, DE;
Norbert Beier, Reinheim, DE;
Oliver Poeschke, Wiesbaden, DE;
Lars Burgdorf, Frankfurt am Main, DE;
Helga Drosdat, Heppenheim, DE;
Florian Lang, Tübingen, DE;
Rolf Gericke, Seeheim-Jugenheim, DE;
Norbert Beier, Reinheim, DE;
Oliver Poeschke, Wiesbaden, DE;
Lars Burgdorf, Frankfurt am Main, DE;
Helga Drosdat, Heppenheim, DE;
Florian Lang, Tübingen, DE;
Merck Patent GmbH, Darmstadt, DE;
Abstract
The invention relates to acylhydrazone derivatives of formula (I), which are SGK inhibitors and can be used for the treatment of diseases and afflictions associated with SGK, such as diabetes, obesity, metabolic syndrome (dyslipidaemia), systematic and pulmonary hypertension, cardiovascular diseases and kidney diseases and in general for all types of fibroses and inflammatory processes. In said formula: Rand Rindependently of one another represent H, OH, OA, OAc or methyl; R, R, R, R, R, R, Rand Rindependently of one another represent H, OH, OA, OAc, OCF, Hal, NO, CF, A, CN, OSOCH, SOCH, NH, or COOH; Rrepresents H or CH; A represents an alkyl comprising 1, 2, 3, or 4 C atoms; X represents CH, CHCH, OCHor —CH(OH)— and Hal represents F, Cl, Br or I.