The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 29, 2008

Filed:

Aug. 18, 2005
Applicants:

Charles L. Cywin, Bethel, CT (US);

Zhidong Chen, New Milford, CT (US);

Jonathan Emeigh, Danbury, CT (US);

Roman Wolfgang Fleck, Greenwich, CT (US);

Ming-hong Hao, Ridgefield, CT (US);

Eugene Hickey, Danbury, CT (US);

Weimin Liu, Sandy Hook, CT (US);

Daniel Richard Marshall, Norwalk, CT (US);

Tina Morwick, New Milford, CT (US);

Peter Nemoto, Southbury, CT (US);

Ronald John Sorcek, Bethel, CT (US);

Sanxing Sun, Danbury, CT (US);

Jiang-ping Wu, Danbury, CT (US);

Inventors:

Charles L. Cywin, Bethel, CT (US);

Zhidong Chen, New Milford, CT (US);

Jonathan Emeigh, Danbury, CT (US);

Roman Wolfgang Fleck, Greenwich, CT (US);

Ming-Hong Hao, Ridgefield, CT (US);

Eugene Hickey, Danbury, CT (US);

Weimin Liu, Sandy Hook, CT (US);

Daniel Richard Marshall, Norwalk, CT (US);

Tina Morwick, New Milford, CT (US);

Peter Nemoto, Southbury, CT (US);

Ronald John Sorcek, Bethel, CT (US);

Sanxing Sun, Danbury, CT (US);

Jiang-Ping Wu, Danbury, CT (US);

Assignee:
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A01N 43/42 (2006.01); A61K 31/44 (2006.01); C07D 471/02 (2006.01); C07D 491/02 (2006.01); C07D 498/02 (2006.01); C07D 513/02 (2006.01); C07D 515/02 (2006.01);
U.S. Cl.
CPC ...
Abstract

Disclosed are compounds of formula (I): wherein Rand Rare defined herein, which are useful as inhibitors of the kinase activity of the IκB kinase (IKK) complex. The compounds are therefore useful in the treatment of IKK mediated diseases including autoimmune diseases inflammatory diseases and cancer. Also disclosed are pharmaceutical compositions comprising these compounds and processes for preparing these compounds.


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