The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 29, 2008
Filed:
Jun. 14, 2005
Robert Wells Marquis, Jr., Wayne, PA (US);
Yu RU, Wayne, PA (US);
Daniel Frank Veber, Ambler, PA (US);
Maxwell David Cummings, Strafford, PA (US);
Scott Kevin Thompson, Phoenixville, PA (US);
Dennis Shinji Yamashita, Wayne, PA (US);
Robert Wells Marquis, Jr., Wayne, PA (US);
Yu Ru, Wayne, PA (US);
Daniel Frank Veber, Ambler, PA (US);
Maxwell David Cummings, Strafford, PA (US);
Scott Kevin Thompson, Phoenixville, PA (US);
Dennis Shinji Yamashita, Wayne, PA (US);
SmithKline Beecham Corporation, Philadelphia, PA (US);
SmithKline Beecham p.l.c., Brentford, Middlesex, GB;
Abstract
The present invention provides 4-amino-azepan-3-one protease inhibitors and pharmaceutically acceptable salts, hydrates and solvates thereof which inhibit proteases, including cathepsin K, pharmaceutical compositions of such compounds, novel intermediates of such compounds, and methods for treating diseases of excessive bone loss or cartilage or matrix degradation, including osteoporosis; gingival disease including gingivitis and periodontitis; arthritis, more specifically, osteoarthritis and rheumatoid arthritis; Paget's disease; hypercalcemia of malignancy; and metabolic bone disease, comprising inhibiting said bone loss or excessive cartilage or matrix degradation by administering to a patient in need thereof a compound of the present invention.