The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 29, 2008
Filed:
Aug. 20, 2003
Scot W. Ebbinghaus, Tucson, AZ (US);
Laurence H. Hurley, Tucson, AZ (US);
Adam Siddiqui-jain, San Diego, CA (US);
Regan Memmott, Tucson, AZ (US);
Scot W. Ebbinghaus, Tucson, AZ (US);
Laurence H. Hurley, Tucson, AZ (US);
Adam Siddiqui-Jain, San Diego, CA (US);
Regan Memmott, Tucson, AZ (US);
Arizona Board of Regents on behalf of the University of Arizona, Tuscon, AZ (US);
Abstract
Among the different intrastrand quadruplex structures that can arise from duplex DNA, it has been discovered that the nucleotide sequences (GGA)(SEQ ID NO: 1) and (GGA)GG (SEQ ID NO: 2) form biologically significant quadruplex structures. Thus, provided herein are methods for identifying molecules that modulate the biological activity of quadruplex DNA comprising the nucleotide sequence (GGA)(SEQ ID NO: 1) or the nucleotide sequence (GGA)GG (SEQ ID NO: 2), and specifically, methods for identifying molecules that bind such quadruplexes. Also provided herein are methods for modulating the biological activity of a biologically significant native quadruplex DNA with a molecule identified by the methods described herein.