The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 22, 2008

Filed:

Apr. 01, 2003
Applicants:

David Gene Barrett, Henstedt-Ulzburg, DE;

John G. Catalano, Durham, NC (US);

David Norman Deaton, Durham, NC (US);

Aaron Bayne Miller, Durham, NC (US);

John A. Ray, Durham, NC (US);

Vicente Samano, Durham, NC (US);

Inventors:

David Gene Barrett, Henstedt-Ulzburg, DE;

John G. Catalano, Durham, NC (US);

David Norman Deaton, Durham, NC (US);

Aaron Bayne Miller, Durham, NC (US);

John A. Ray, Durham, NC (US);

Vicente Samano, Durham, NC (US);

Assignee:

SmithKline Beecham Corporation, Philadelphia, PA (US);

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/341 (2006.01); A61K 31/4015 (2006.01); A61K 31/4025 (2006.01); A61K 31/404 (2006.01); A61K 31/4155 (2006.01); A61K 31/416 (2006.01); A61K 31/4192 (2006.01); A61K 31/4196 (2006.01); A61K 31/4245 (2006.01); A61K 31/42 (2006.01); A61K 31/433 (2006.01); A61K 31/4439 (2006.01); A61K 31/4709 (2006.01); A61K 31/497 (2006.01); A61K 31/5377 (2006.01);
U.S. Cl.
CPC ...
Abstract

Heterocycle substituted ketoamide derivatives of Formula (I), wherein the substitutes A, D, A and R are defined as in claim in, which are useful as cathepsin K inhibitors are described herein. The described invention also includes methods of making such heterocycle substituted ketoamide derivatives as well as method of using the same in the manufacture of medicaments for the treatment of disorders, including osteoporosis, associated with an imbalance between bone resorption and formation which can ultimately lead to fracture.


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