The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 22, 2008
Filed:
Aug. 28, 2006
Paul D. Ponath, Boston, MA (US);
Douglas J. Ringler, Revere, MA (US);
S. Tarran Jones, Radlett, GB;
Walter Newman, Boston, MA (US);
José Saldanha, Middlesex, GB;
Mary M. Bendig, London, GB;
Paul D. Ponath, Boston, MA (US);
Douglas J. Ringler, Revere, MA (US);
S. Tarran Jones, Radlett, GB;
Walter Newman, Boston, MA (US);
José Saldanha, Middlesex, GB;
Mary M. Bendig, London, GB;
Millennium Pharmaceuticals, Inc., Cambridge, MA (US);
Abstract
The present invention relates to isolated nucleic acids encoding humanized immunoglobulins having binding specificity for α4β7 integrin, isolated nucleic acids encoding a humanized immunoglobulin heavy chain and isolated nucleic acids encoding a humanized light chain having binding specificity for α4β7 integrin. The invention also relates to expression vectors and host cells comprising a nucleotide sequence which encodes a humanized immunoglobulin or antigen-binding fragment thereof having binding specificity for α4β7. The invention further relates to methods of preparing a humanized immunoglobulin, humanized immunoglobulin heavy chain and humanized immunoglobulin light chain that has binding specificity for α4β7 integrin.