The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 22, 2008
Filed:
Aug. 10, 2004
Po-ying Chan-hui, Oakland, CA (US);
Sharat Singh, Los Altos, CA (US);
Hossein Salimi-moosavi, Sunnyvale, CA (US);
Hasan Tahir, Foster City, CA (US);
Gerald J. Wallweber, La Honda, CA (US);
Hrair Kirakosssian, San Jose, CA (US);
Tracy J. Matray, Campbell, CA (US);
Po-Ying Chan-Hui, Oakland, CA (US);
Sharat Singh, Los Altos, CA (US);
Hossein Salimi-Moosavi, Sunnyvale, CA (US);
Hasan Tahir, Foster City, CA (US);
Gerald J. Wallweber, La Honda, CA (US);
Hrair Kirakosssian, San Jose, CA (US);
Tracy J. Matray, Campbell, CA (US);
Monogram BioSciences, Inc., South San Francisco, CA (US);
Abstract
Methods are provided for detecting the formation of complexes of molecules, especially proteins, in a sample, such as a cell or tissue lysate. In one aspect, a cleaving probe specific for a first protein in a complex and one or more binding compounds specific for one or more second proteins in a complex are provided. Upon binding, the cleaving probe is induced to generate an active species, such as singlet oxygen, that cleaves molecular tags attached to the binding compounds only in the local region of the cleaving probe. The released molecular tags are separated from the assay mixture and from one another to provide a readout that is related to the number and types of proteins present in the complex.