The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 22, 2008
Filed:
Oct. 03, 2001
Applicants:
Amanda Proudfoot, Chens-sur-Léman, FR;
Timothy N. C. Wells, Prevessin Moens, FR;
Marie Kosco-vilbois, Minzier, FR;
Inventors:
Amanda Proudfoot, Chens-sur-Léman, FR;
Timothy N. C. Wells, Prevessin Moens, FR;
Marie Kosco-Vilbois, Minzier, FR;
Assignee:
Laboratoires Serono SA, Coinsins, Vaud, CH;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 45/00 (2006.01); C12P 21/00 (2006.01);
U.S. Cl.
CPC ...
Abstract
Mutants of CC chemokines, which contain at least two mutations in the cationic site of the 40's loop and which, relative to the wild-type molecule, have a reduced GAG-binding activity. In particular it has been found that such mutated chemokines are effective in the treatment of multiple sclerosis and/or demyelinating diseases. A triple mutant of RANTES is the compound showing the best results.