The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 15, 2008
Filed:
Aug. 05, 2002
David W. Borhani, Worcester, MA (US);
David Calderwood, Framingham, MA (US);
Richard W. Dixon, Jefferson, MA (US);
Gavin C. Hirst, Princeton, MA (US);
Peter Hrnciar, Lexington, MA (US);
Andreas Loew, Worcester, MA (US);
Adelaine Leung, Mississauga, CA;
Kurt Ritter, Frankfurt, DE;
David W. Borhani, Worcester, MA (US);
David Calderwood, Framingham, MA (US);
Richard W. Dixon, Jefferson, MA (US);
Gavin C. Hirst, Princeton, MA (US);
Peter Hrnciar, Lexington, MA (US);
Andreas Loew, Worcester, MA (US);
Adelaine Leung, Mississauga, CA;
Kurt Ritter, Frankfurt, DE;
Abbott Laboratories, Abbott Park, IL (US);
Abstract
The present invention relates to polypeptides which comprise the ligand binding domain of Lck, crystalline forms of these polypeptides, and the use of these crystalline forms to determine the three dimensional structure of the catalytic domain of Lck. The invention also relates to the use of the three dimensional structure of the Lck catalytic domain both alone, or in complex with inhibitors, in methods of designing and/or identifying potential inhibitors of Lck activity, for example, compounds which inhibit the binding of a native substrate to the Lck catalytic domain. The invention also relates to the use of the three dimensional structure of the Lck catalytic domain both alone, or in complex with inhibitors, in methods of designing and/or identifying potential selective inhibitors of Lck activity, for example, compounds which inhibit the binding of a native substrate to the Lck catalytic domain selectively.