IDiyas

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 7399765 B1

PDFFull Text
Date of Patent:
Jul. 15, 2008

Filed:

Sep. 16, 2004

Substituted diazabicycloalkane derivatives

Applicants:

William H. Bunnelle, Mundelein, IL (US);

Jianguo Ji, Libertyville, IL (US);

Tao LI, Grayslake, IL (US);

Jennifer M. Pace, Grayslake, IL (US);

Karin R. Tietje, Mundelein, IL (US);

Kathleen H. Mortell, Chicago, IL (US);

Diana L. Nersesian, Gurnee, IL (US);

Michael R. Schrimpf, Grayslake, IL (US);

Inventors:

William H. Bunnelle, Mundelein, IL (US);

Jianguo Ji, Libertyville, IL (US);

Tao Li, Grayslake, IL (US);

Jennifer M. Pace, Grayslake, IL (US);

Karin R. Tietje, Mundelein, IL (US);

Kathleen H. Mortell, Chicago, IL (US);

Diana L. Nersesian, Gurnee, IL (US);

Michael R. Schrimpf, Grayslake, IL (US);

Assignee:

Abbott Laboratories, Abbott Park, IL (US);

Attorney:

Sreenivasarao Vepachedu

Primary Examiner:

Mark L Berch

Assistant Examiner:

Cecilia M Jaisle

Int. Cl.
CPC ...
A61K 31/501 (2006.01); A61K 31/5025 (2006.01); A61K 31/4427 (2006.01); A61K 31/42 (2006.01); A61K 31/4436 (2006.01); C07D 401/04 (2006.01); C07D 403/04 (2006.01); C07D 405/04 (2006.01); C07D 409/04 (2006.01); C07D 471/04 (2006.01); C07D 491/04 (2006.01); C07D 498/04 (2006.01); C07D 513/04 (2006.01); C07D 515/04 (2006.01); A61P 29/00 (2006.01); C07D 231/12 (2006.01); C07D 417/04 (2006.01); C07D 285/08 (2006.01); C07D 285/12 (2006.01); C07D 239/42 (2006.01); C07D 263/34 (2006.01); C07D 413/02 (2006.01); C07D 413/14 (2006.01); C07D 271/107 (2006.01); C07D 487/04 (2006.01); C07D 215/12 (2006.01); C07D 261/12 (2006.01); C07D 401/14 (2006.01); C07D 413/04 (2006.01); C07D 23/56 (2006.01); A61K 31/41 (2006.01); A61K 31/425 (2006.01); A61K 31/426 (2006.01); A61K 31/427 (2006.01); A61K 31/4245 (2006.01); A61K 31/441 (2006.01); A61K 31/422 (2006.01); A61K 31/4155 (2006.01);
U.S. Cl.
CPC ...
Abstract

Compounds of formula (I)Z-Ar—Ar  (I)wherein Z is a diazabicyclic amine, Aris a 5- or 6-membered aromatic ring, and Aris selected from the group consisting of an unsubstituted or substituted 5- or 6-membered heteroaryl ring; unsubstituted or substituted bicyclic heteroaryl ring; 3,4-(methylenedioxy)phenyl; carbazolyl; tetrahydrocarbazolyl; naphthyl; and phenyl; wherein the phenyl is substituted with 0, 1, 2, or 3 substituents in the meta- or para-positions. The compounds are useful in treating conditions or disorders prevented by or ameliorated by α7 nAChR ligands. Also disclosed are pharmaceutical compositions comprising compounds of formula (I) and methods for using such compounds and compositions.

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