The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 15, 2008
Filed:
Sep. 22, 2004
Dudley J. Williams, Laguna Niguel, CA (US);
Marcella Gilmore, Santa Ana, CA (US);
Lance Steward, Irvine, CA (US);
Marc Verhagen, Irvine, CA (US);
Kei Roger Aoki, Coto de Caza, CA (US);
Dudley J. Williams, Laguna Niguel, CA (US);
Marcella Gilmore, Santa Ana, CA (US);
Lance Steward, Irvine, CA (US);
Marc Verhagen, Irvine, CA (US);
Kei Roger Aoki, Coto de Caza, CA (US);
Allergan, Inc., Irvine, CA (US);
Abstract
The present invention provides a method of determining the presence or activity of a clostridial toxin by (a) treating with a sample, under conditions suitable for clostridial toxin protease activity, a clostridial toxin substrate which includes a fluorophore; a bulking group; and a clostridial toxin recognition sequence containing a cleavage site that intervenes between the fluorophore and the bulking group; (b) exciting the fluorophore with plane polarized light; and (c) determining fluorescence polarization of the treated substrate relative to a control substrate, where a change in fluorescence polarization of the treated substrate as compared to fluorescence polarization of the control substrate is indicative of the presence or activity of the clostridial toxin.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile