The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 08, 2008
Filed:
Feb. 24, 2006
David S. Garvey, Dover, MA (US);
L. Gordon Letts, Dover, MA (US);
Richard A. Earl, Westford, MA (US);
Maiko Ezawa, San Diego, CA (US);
Xinqin Fang, Lexington, MA (US);
Ricky D. Gaston, Malden, MA (US);
Subhash P. Khanapure, Littleton, MA (US);
Chia-en Lin, Concord, MA (US);
Ramani R. Ranatunge, Lexington, MA (US);
Cheri A. Stevenson, Haverhill, MA (US);
Shiow-jyi Wey, Billerica, MA (US);
David S. Garvey, Dover, MA (US);
L. Gordon Letts, Dover, MA (US);
Richard A. Earl, Westford, MA (US);
Maiko Ezawa, San Diego, CA (US);
Xinqin Fang, Lexington, MA (US);
Ricky D. Gaston, Malden, MA (US);
Subhash P. Khanapure, Littleton, MA (US);
Chia-En Lin, Concord, MA (US);
Ramani R. Ranatunge, Lexington, MA (US);
Cheri A. Stevenson, Haverhill, MA (US);
Shiow-Jyi Wey, Billerica, MA (US);
Nitromed, Inc., Lexington, MA (US);
Abstract
The invention describes novel compositions and kits comprising at least one nitric oxide enhancing diuretic compound, or pharmaceutically acceptable salts thereof, and, optionally, at least one nitric oxide enhancing compound and/or at least one therapeutic agent. The invention also provides methods for (a) treating conditions resulting from excessive water and/or electrolyte retention; (b) treating cardiovascular diseases; (c) treating renovascular diseases; (d) treating diabetes; (e) treating diseases resulting from oxidative stress; (f) treating endothelial dysfunctions; (g) treating diseases caused by endothelial dysfunctions; (h) treating cirrhosis; (j) treating pre-eclampsia; (k) treating osteoporosis; (l) treating nephropathy; (m) treating peripheral vascular diseases; (n) treating portal hypertension; (o) treating central nervous system disorders; (p) treating metabolic syndrome; (q) treating sexual dysfunctions; and (r) hyperlipidemia. The nitric oxide enhancing diuretic compounds comprise at least one nitric oxide enhancing group linked to the diuretic compound through one or more sites such as carbon, oxygen and/or nitrogen via a bond or moiety that cannot be hydrolyzed.