The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 08, 2008
Filed:
Nov. 07, 2003
Tim Patno, Chicago, IL (US);
Jennifer Hollenstein, Grayslake, IL (US);
Christian Kronshage, Round Lake, IL (US);
Christopher Khoury, Chicago, IL (US);
Mark Weber, Algonquin, IL (US);
Tom Westberg, Gurnee, IL (US);
William Cork, Lake Bluff, IL (US);
Tim Patno, Chicago, IL (US);
Jennifer Hollenstein, Grayslake, IL (US);
Christian Kronshage, Round Lake, IL (US);
Christopher Khoury, Chicago, IL (US);
Mark Weber, Algonquin, IL (US);
Tom Westberg, Gurnee, IL (US);
William Cork, Lake Bluff, IL (US);
Nanosphere, Inc., Northbrook, IL (US);
Abstract
A method and apparatus are provided for preparing a test sample for detecting a predetermined target nucleic acid. The method includes the steps of providing a test probe comprising an oligonucleotide attached to a nanoparticle and providing a hybridization unit containing the test sample and the test probe, wherein said hybridization unit further includes a target sample substrate and a distribution manifold coupled to a first side of the substrate. The method further includes the steps of clamping a processing fluids manifold to the distribution manifold of the hybridization unit, denaturing the test sample and preparing the test sample for detecting the predetermined target nucleic acid by pumping a plurality of processing fluids between the processing fluids source manifold and distribution manifold to hybridize the test probe and predetermined target nucleic acid to the target sample substrate, to wash the hybridized sample and to amplify a detectable parameter of the hybridized sample.