The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 01, 2008
Filed:
Dec. 01, 2004
Hubert Hertenberger, Weilheim, DE;
Konrad Honold, Penzberg, DE;
Christian Klein, Iffeldorf, DE;
Petra Rueger, Penzberg, DE;
Hubert Hertenberger, Weilheim, DE;
Konrad Honold, Penzberg, DE;
Christian Klein, Iffeldorf, DE;
Petra Rueger, Penzberg, DE;
Hoff Hoffmann-La Roche Inc., Nutley, NJ (US);
Abstract
A method for the recombinant production and purification of a protein kinase selected from the group consisting of tyrosine protein kinases and serine/threonine kinases by expressing a nucleic acid encoding said kinase in a microbial host cell, forming inclusion bodies containing said kinase, isolating, solubilizing, naturing, and purifying said kinase wherein said purification is performed by hydrophobic interaction with an hydrophobic adsorbent under conditions whereby at least 70% of said protein kinase are not bound to said adsorbent and the protein kinase not bound to said adsorbent is recovered.