The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 24, 2008
Filed:
Oct. 23, 2003
Robert Davies, Arlington, MA (US);
David Bebbington, Newbury, GB;
Ronald Knegtel, Abingdom, GB;
Marion Wannamaker, Stow, MA (US);
Pan LI, Arlington, MA (US);
Cornelia Forster, Pelham, NH (US);
Albert Pierce, Somerville, MA (US);
Robert Davies, Arlington, MA (US);
David Bebbington, Newbury, GB;
Ronald Knegtel, Abingdom, GB;
Marion Wannamaker, Stow, MA (US);
Pan Li, Arlington, MA (US);
Cornelia Forster, Pelham, NH (US);
Albert Pierce, Somerville, MA (US);
Vertex Pharmaceuticals Incorporated, Cambridge, MA (US);
Abstract
This invention describes novel pyrazole compounds of formula II: wherein Ring C is selected from a phenyl, pyridinyl, pyrimidinyl, pyridazinyl, pyrazinyl, or 1,2,4-triazinyl ring, and R, R, R, and Rare as described in the specification. Ring C has an ortho substituent and is optionally substituted in the non-ortho positions. Rand Rare optionally taken together with their intervening atoms to form a fused ring system, such as an indazole ring; and Rand Rare optionally taken together with their intervening atoms to form a fused ring system, such as a quinazoline ring. The compounds are useful as protein kinase inhibitors, especially as inhibitors of GSK-3, for treating diseases such as diabetes and Alzheimer's disease.