The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 24, 2008
Filed:
Dec. 13, 2004
Roger Briesewitz, Mountain View, CA (US);
Gerald R. Crabtree, Woodside, CA (US);
Thomas Wandless, Menlo Park, CA (US);
Gregory Thomas Ray, Stanford, CA (US);
Kurt W. Vogel, Palo Alto, CA (US);
Roger Briesewitz, Mountain View, CA (US);
Gerald R. Crabtree, Woodside, CA (US);
Thomas Wandless, Menlo Park, CA (US);
Gregory Thomas Ray, Stanford, CA (US);
Kurt W. Vogel, Palo Alto, CA (US);
The Board of Trustees of the Leland Stanford Junior University, Palo Alto, CA (US);
Abstract
Bifunctional molecules and methods for their use in the production of binary complexes in a host are provided. The bifunctional molecule is a conjugate of a drug moiety and a presenter protein ligand. In the subject methods, an effective amount of the bifunctional molecule is administered to the host. The bifunctional molecule binds to the presenter protein to produce a binary complex that exhibits at least one of improved affinity, specificity or selectivity as compared to the corresponding free drug. The subject methods and compositions find use in a variety of therapeutic applications.