The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 24, 2008
Filed:
Sep. 25, 2000
Fionula Mary Brennan, London, GB;
Marc Feldmann, London, GB;
Brian Maurice John Foxwell, London, GB;
Fionula Mary Brennan, London, GB;
Marc Feldmann, London, GB;
Brian Maurice John Foxwell, London, GB;
Abstract
A method of identifying a compound with efficacy in the treatment of chronic inflammatory disease by testing the compound for an ability to selectively inhibit the ability of Tcells to induce pro-inflammatory cytokine release from a monocyte is disclosed. The method includes pre-incubatin Tcells with a compound to be tested, optionally resuspending the Tcells in the absence of the test compound, co-culturing the Tcells with monocytes, and assaying for the production of pro-inflammatory cytokines by the monocytes. The Tcells are produced by incubating a population of T cells with one or more cytokines or the Tcells are isolated from synovial tissue. The Tcells have not been contacted with an anti-CD3 antibody. The ability to selectively inhibit cytokine release indicates that the compound has efficacy in the treatment of chronic inflammatory disease.