Cyclohexyl(alkyl)-propanolamines, preparation method and pharmaceutical compositions containing same

Abstract

The present invention relates to the compounds of formula (I): in which A is a group of formula (a) or (b) in which R represents a hydrogen or halogen atom, an —S(O)(C–C)alkyl group, an —NHSO(C–C)alkyl group, an —SONH(C–C)alkyl group, an —NHSOphenyl-(C–C)alkyl group or an —NHSOphenyl group, said phenyl possibly being substituted with a halogen atom, with a (C–C)alkyl group or with a (C–C)alkoxy group; Rrepresents a hydrogen atom or a (C–C)alkyl group, a —CO(C–C)alkyl group, a phenyl-(C–C)alkyl group or a —COphenyl group, said phenyl also possibly being substituted with a halogen atom or with a (C–C)alkoxy group; Ris a hydrogen atom or an —SO(C–C)alkyl group, an —SOphenyl-(C–C)alkyl group or an —SOphenyl group; X completes a ring of 5 to 8 atoms, said ring being saturated or unsaturated, possibly being substituted with one or two (C–C)alkyl groups and bearing one or two carbonyl groups; n, m and z are, independently, 0, 1 or 2; Rrepresents a hydrogen or halogen atom, a (C–C)alkyl group, a (C–C)alkoxy group, a —COO(C–C)alkyl group, a —CO(C–C)alkyl group, an —NHSO(C–C)alkyl group, an —NHSOphenyl-(C–C)alkyl groups, —NO, —CN, —CONRR, —COOH, or a 4,5-dihydro-1,3-oxazol-2-yl or 4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl group; Rand Rrepresent, independently, a hydrogen atom, a phenyl, a (C–C)alkyl group or a phenyl-(C–C)alkyl group or Rand Rwith the nitrogen atom to which they are attached, may form a ring of 5 to 7 atoms in total; and to the salts or solvates thereof, to the pharmaceutical compositions containing them, to a process for the preparation thereof and to intermediates in this process.