The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 10, 2008
Filed:
May. 07, 2004
René Coulombe, Montréal, CA;
Pierre Beaulieu, Laval, CA;
Eric Jolicoeur, Laval, CA;
George Kukolj, Mont-Royal, CA;
Steven Laplante, Bois-des-Filion, CA;
Marc-andré Poupart, Laval, CA;
René Coulombe, Montréal, CA;
Pierre Beaulieu, Laval, CA;
Eric Jolicoeur, Laval, CA;
George Kukolj, Mont-Royal, CA;
Steven Laplante, Bois-des-Filion, CA;
Marc-André Poupart, Laval, CA;
Boehringer Ingelheim International GmbH, Ingelheim, DE;
Abstract
The HCV NS5B polymerase, when complexed with certain inhibitors, adopts a conformation in which the finger loop region defined by amino acid residues 18 to 35 is displaced to expose a binding pocket defined generally by amino acid residues 392, 393, 395, 396, 399, 424, 425, 428, 429, 492, 493, 494, 495, 496, 500 and 503. This newly exposed binding pocket defines a novel target in the search of further chemical entities which are capable of binding to HCV NS5B and modulating, or preferably inhibiting, the polymerase activity of HCV NS5B.