The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 10, 2008
Filed:
Jan. 22, 2002
Thomas Arrhenius, Del Mar, CA (US);
MI Chen, San Diego, CA (US);
Jie Fei Cheng, Carlsbad, CA (US);
Yujin Huang, San Diego, CA (US);
Alex Michael Nadzan, Encinitas, CA (US);
Sovouthy Tith, San Diego, CA (US);
Masayuki Haramura, Chiba, JP;
David Mark Wallace, San Diego, CA (US);
Steve Joel Brown, San Diego, CA (US);
Charles Stanford Harmon, Rancho Santa Fe, CA (US);
Lin Zhang, San Diego, CA (US);
Gary D. Lopaschuk, Edmonton, CA;
Jason R. Dyck, Sherwood Park, CA;
Thomas Arrhenius, Del Mar, CA (US);
Mi Chen, San Diego, CA (US);
Jie Fei Cheng, Carlsbad, CA (US);
Yujin Huang, San Diego, CA (US);
Alex Michael Nadzan, Encinitas, CA (US);
Sovouthy Tith, San Diego, CA (US);
Masayuki Haramura, Chiba, JP;
David Mark Wallace, San Diego, CA (US);
Steve Joel Brown, San Diego, CA (US);
Charles Stanford Harmon, Rancho Santa Fe, CA (US);
Lin Zhang, San Diego, CA (US);
Gary D. Lopaschuk, Edmonton, CA;
Jason R. Dyck, Sherwood Park, CA;
Chugai Seiyaku Kabushiki Kaisha, Tokyo, JP;
Abstract
The present invention relates to methods for the prophylaxis, management and treatment of certain diseases modulated by the inhibition of the enzyme malonyl-coenzyme A decarboxylase (malonyl-CoA decarboxylase, MCD) by the administration of a composition containing as an active ingredient a compound according to Formula I. In particular, the invention relates to methods for the prophylaxis, management and treatment of cardiovascular diseases, diabetes, acidosis, cancers, and obesity through the administration of a compound which inhibits malonyl-coenzyme A decarboxylase activity. The present invention also includes within its scope the novel process for the preparation of certain compounds