Thieno(3,2-d)pyrimidines and furano(3,2-d)pyrimidines and their use as purinergic receptor antagonists

Abstract

A compound of formula (I), wherein X is S or O; Ris selected from H, alkyl, aryl, hydroxy, alkoxy, aryloxy, thioalkyl, thioaryl, halogen, CN, COR, COR, CONRR, CONRNRR, NRR, NRCONRR, NRCOR, NRCOR, and NRSOR; Ris selected from aryl attached via an unsaturated carbon atom; Ris selected from H, alkyl, hydroxy, alkoxy, halogen, CN and NO; Ris selected from H, alkyl, aryl, hydroxy, alkoxy, aryloxy, thioalkyl, thioaryl, halogen, CN, NO, COR, COR, CONRR, CONRNRR, NRR, NRCONRR, NRCOR, NRCORand NRSOR; R, Rand Rare independently selected from H, alkyl and aryl or where Rand Rare in an (NRR) group, Rand Rmay be linked to form a heterocyclic group, or where R, Rand Rare in a (CONRNRR) group, Rand Rmay be linked to form a heterocyclic group; and Ris selected from alkyl and aryl, or a pharmaceutically acceptable salt thereof or prodrug thereof, and the use thereof in therapy and in the treatment or prevention of a disorder in which the blocking of purine receptors, particularly adenosine receptors and more particularly Areceptors, may be beneficial, particularly wherein said disorder is a movement disorder such a Parkinson's disease or said disorder is depression, cognitive or memory impairment, acute or chronic pain, ADHD or narcolepsy, or wherein said medicament is for neuroprotection in a subject