The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 10, 2008
Filed:
Jul. 28, 2003
Thomas Daniel Aicher, Superior, CO (US);
Zhaogen Chen, Noblesville, IN (US);
Yvan Lehuerou, Boulder, CO (US);
Fionna Mitchell Martin, Basingstoke, GB;
Marta Maria Pineiro-nunez, Brownsburg, IN (US);
Vincent Patrick Rocco, Indianapolis, IN (US);
Kevin Michael Ruley, Indianapolis, IN (US);
John Mehnert Schaus, Zionsville, IN (US);
Patrick Gianpietro Spinazze, Avon, IN (US);
David Edward Tupper, Basingstoke, GB;
Thomas Daniel Aicher, Superior, CO (US);
Zhaogen Chen, Noblesville, IN (US);
Yvan LeHuerou, Boulder, CO (US);
Fionna Mitchell Martin, Basingstoke, GB;
Marta Maria Pineiro-Nunez, Brownsburg, IN (US);
Vincent Patrick Rocco, Indianapolis, IN (US);
Kevin Michael Ruley, Indianapolis, IN (US);
John Mehnert Schaus, Zionsville, IN (US);
Patrick Gianpietro Spinazze, Avon, IN (US);
David Edward Tupper, Basingstoke, GB;
Eli Lilly and Company, Indianapolis, IN (US);
Abstract
Described herein are compounds of formula (I) wherein: is an optionally benzo-fused five or six member aromatic ring having zero to three hetero atoms independently selected from N, S, and O; Alk is (C) alkylene or hydroxy substituted (C) alkylene; X is oxygen or sulfur; Ris hydrogen, (C) fluroalkyl, (C) cycloalkyl, or (C) alkyl, wherein the (C) alkyl is unsubstituted or substituted with hydroxy, methoxy, ethoxy, OCHCHOH, or —CN; Ris H, halogen, (C) fluoroalkyl, (C) cycloalkyl, OR, SR, NO, CN, COR, C(O)OR, CONRR, NRR, SONRR, NRCOR, NRSOR, optionally substituted aromatic, or (C) alkyl, wherein (C) alkyl is unsubstituted or substituted with a hydroxy group; Ris hydrogen (C) fluoroalkyl, (C) alkenyl, Ar, (C)alkyl-Ar, or (C) alkyl wherein (C) alkyly is unsubstituted or substituted with a phenyl; Ris hydrogen, (C) alkyl, (C) fluoroalkyl, or optionally substituted aromatic; Rand Rare independently hydrogen, (C) alkyl, or optionally substituted aromatic, Ris hydrogen, (C) alkyl, (C) fluoroalkyl, or optionally substituted aromatic; Rand Rare independently hydrogen, (C) alkyl, or optionally substituted aromatic; Ar is optionally substituted phenyl, napthyl, monocyclic heteroaromatic or bicyclic heteroaromatic; Zand Zare independently selected from hydrogen, halogen, (C) alkyl, (C) fluoroalkyl, OR, SR, NO, CN, COR, CONRR, NRR, and optionally substituted aromatic; and all salts, solvates, optical and geometric isomers, and crystalline forms thereof. Also, described are the use of the compounds of formula (I) as antagonists of the dopamine D2 receptor and as agents for the treatment of psychosis and bipolar disorders, and pharmaceutical formulations of the compounds of formula (I)