The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 10, 2008
Filed:
Sep. 30, 1999
Randall K. Holmes, Golden, CO (US);
Michael G. Jobling, Aurora, CO (US);
John H. Eldridge, Fairport, NY (US);
Bruce A. Green, Pittsford, NY (US);
Gerald E. Hancock, Honeoye Falls, NY (US);
Joel A. Peek, Brentwood, TN (US);
Randall K. Holmes, Golden, CO (US);
Michael G. Jobling, Aurora, CO (US);
John H. Eldridge, Fairport, NY (US);
Bruce A. Green, Pittsford, NY (US);
Gerald E. Hancock, Honeoye Falls, NY (US);
Joel A. Peek, Brentwood, TN (US);
Wyeth Holdings Corporation, Madison, NJ (US);
The United States of America as represented by the Uniformed Services University of the Health Sciences, Washington, DC (US);
Abstract
A mutant cholera holotoxin featuring a point mutation at amino acid 29 of the A subunit, wherein the glutamic acid residue is replaced by an amino acid other than aspartic acid, is useful as an adjuvant in an antigenic composition to enhance the immune response in a vertebrate host to a selected antigen from a pathogenic bacterium, virus, fungus or parasite. In a particular embodiment, the amino acid 29 is histidine. The mutant cholera holotoxin may contain at least one additional mutation in the A subunit at a position other than amino acid 29. The antigenic composition may include a second adjuvant in addition to the mutant cholera holotoxin.