The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 10, 2008
Filed:
Sep. 06, 2005
Andrew S. Kende, Pittsford, NY (US);
Barbara H. Iglewski, Fairport, NY (US);
Roger Smith, Rochester, NY (US);
Richard P. Phipps, Pittsford, NY (US);
James P. Pearson, Fremont, CA (US);
Andrew S. Kende, Pittsford, NY (US);
Barbara H. Iglewski, Fairport, NY (US);
Roger Smith, Rochester, NY (US);
Richard P. Phipps, Pittsford, NY (US);
James P. Pearson, Fremont, CA (US);
University of Rochester, Rochester, NY (US);
Abstract
The present invention relates to an immunogenic conjugate comprising a carrier molecule coupled to an autoinducer of a Gram negative bacteria The immunogenic conjugate, when combined with a pharmaceutically acceptable carrier, forms a suitable vaccine for mammals to prevent infection by the Gram negative bacteria The immunogenic conjugate is also used to raise and subsequently isolate antibodies or binding portions thereof which are capable of recognizing and binding to the autoinducer. The antibodies or binding portions thereof are utilized in a method of treating infections, a method of inhibiting autoinducer activity, and in diagnostic assays which detect the presence of autoinducers or autoinducer antagonists in fluid or tissue samples.