The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 03, 2008
Filed:
Nov. 28, 2003
Masaomi Tajimi, Aichi-ken, JP;
Toshio Kokubo, Nara-ken, JP;
Masahiro Shiroo, Cambridge, GB;
Yasuhiro Tsukimi, Hyogo-ken, JP;
Takeshi Yura, Aichi-ken, JP;
Klaus Urbahns, Lund, SE;
Noriyuki Yamamoto, Osaka-fu, JP;
Muneto Mogi, Nara-ken, JP;
Hiroshi Fujishima, Nara-ken, JP;
Tsutomu Masuda, Aichi-ken, JP;
Nagahiro Yoshida, Kyoto-fu, JP;
Toshiya Moriwaki, Nara-ken, JP;
Masaomi Tajimi, Aichi-ken, JP;
Toshio Kokubo, Nara-ken, JP;
Masahiro Shiroo, Cambridge, GB;
Yasuhiro Tsukimi, Hyogo-ken, JP;
Takeshi Yura, Aichi-ken, JP;
Klaus Urbahns, Lund, SE;
Noriyuki Yamamoto, Osaka-fu, JP;
Muneto Mogi, Nara-ken, JP;
Hiroshi Fujishima, Nara-ken, JP;
Tsutomu Masuda, Aichi-ken, JP;
Nagahiro Yoshida, Kyoto-fu, JP;
Toshiya Moriwaki, Nara-ken, JP;
Xention Limited, Cambridge, GB;
Abstract
This invention relates to tetrahydro-naphthalene derivatives and salts thereof which are useful as active ingredients of pharmaceutical preparations. They have the general formula (I) in which Rrepresents hydrogen or Calkyl, and X represents —N(H)Y, —(H)—CalkyleneY, biphenyl or Calkyl substituted by biphenyl, and the group Yis an optionally substituted biphenyl. The tetrahydro-naphthalene derivatives of the present invention have excellent activity as VR1 antagonists and are useful for the prophylaxis and treatment of diseases associated with VR1 activity, in particular for the treatment of urinary incontinence, overactive bladder, urge urinary incontinence, chronic pain, neuropathic pain, postoperative pain, rheumatoid arthritic pain, neuralgia, neuropathies, algesia, nerve injury, ischaemia, neurodegeneration, stroke, inflammatory disorders, asthma and COPD.