The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 03, 2008

Filed:

Aug. 04, 2003
Applicants:

Stephen Robert Fletcher, Bishops Stortford, GB;

Angus Murray Macleod, Bishops Stortford, GB;

Monique Bodil Van Niel, Welwyn, GB;

Kevin Wilson, West Newton, MA (US);

Inventors:

Stephen Robert Fletcher, Bishops Stortford, GB;

Angus Murray MacLeod, Bishops Stortford, GB;

Monique Bodil Van Niel, Welwyn, GB;

Kevin Wilson, West Newton, MA (US);

Assignee:

Merck Sharp & Dohme Ltd., Hoddesdon, Hertfordshire, GB;

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/501 (2006.01); C07D 401/04 (2006.01); C07D 403/04 (2006.01); C07D 405/04 (2006.01); C07D 409/04 (2006.01); C07D 237/14 (2006.01); C07D 237/20 (2006.01); A61P 25/28 (2006.01);
U.S. Cl.
CPC ...
Abstract

A class of pyridazine derivatives, substituted in the 4-position by an optionally substituted heteroaromatic ring, being selective ligands for GABAA receptors, in particular having high affinity for the α2 and/or α3 and/or α5 subunit thereof, are accordingly of benefit in the treatment and/or prevention of adverse conditions of the central nervous system, including anxiety, convulsions and cognitive disorders.


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