The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 03, 2008
Filed:
Jun. 28, 2007
Murtaza F. Alibhai, Chesterfield, MO (US);
James D. Astwood, Eureka, MO (US);
Charles A. Mcwherter, Chesterfield, MO (US);
Hugh A. Sampson, Larchmont, NY (US);
Murtaza F. Alibhai, Chesterfield, MO (US);
James D. Astwood, Eureka, MO (US);
Charles A. McWherter, Chesterfield, MO (US);
Hugh A. Sampson, Larchmont, NY (US);
Monsanto Technology LLC, St. Louis, MO (US);
Abstract
Modified proteins are disclosed that maintain enzymatic and insecticidal activity while displaying reduced or eliminated allergenicity. Epitopes which bind to anti-patatin antibodies were identified, and removed via site directed mutagenesis. Tyrosines were observed to generally contribute to the allergenic properties of patatin proteins. Removal of glycosylation sites was observed to reduce or eliminate antibody binding. Permuteins are also disclosed which have a rearranged amino acid sequence while retaining enzymatic activity. Deallergenized proteins and permuteins can be used as insecticidal materials, as nutritional supplements, and as immunotherapeutic agents.