The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 03, 2008
Filed:
Jan. 10, 2006
Applicants:
Peter Francis Leadlay, Cambridge, GB;
James Staunton, Cambridge, GB;
Lake EE Khaw, Cambridge, GB;
Inventors:
Assignee:
Biotica Technology Limited, Essex, GB;
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12P 19/62 (2006.01); C12N 1/20 (2006.01); C12Q 1/00 (2006.01);
U.S. Cl.
CPC ...
Abstract
The rapamycin gene cluster is an example of a gene cluster which includes a gene (rapL) leading to the formation of a precursor compound (pipecolic acid, in this case) which is required for inclusion in the larger product (rapamycin) produced by the enzymes encoded by the cluster. We have produced a mutant strain containing a rapamycin gene cluster in which the rapL gene is disabled. The strain does not naturally produce rapamycin but does so if fed with pipecolic acid. By feeding with alternative carboxylic acids we have produced variants of rapamycins. Tests have shown biological activity.