The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 27, 2008
Filed:
Mar. 05, 2002
David H. Coy, New Orleans, LA (US);
William A. Murphy, Slidell, LA (US);
Walajapet G. Rajeswaran, Kalamazoo, MI (US);
David H. Coy, New Orleans, LA (US);
William A. Murphy, Slidell, LA (US);
Walajapet G. Rajeswaran, Kalamazoo, MI (US);
The Administrators of the Tulane Educational Fund, New Orleans, LA (US);
Abstract
The present invention is directed to a somatostatin antagonist according to formula (I), wherein Ais an optionally substituted aromatic ∝-amino acid; Ais an optionally substituted aromatic ∝-amino acid; Ais Dab, Dap, Lys or Orn; Ais β-Hydroxyvaline, Ser, Hser, or Thr; Ais an optionally substituted D- or L-aromatic -amino acid; and Yis OH, NHor NHR, or NHR, where Ris (C)alkyl; wherein each said optionally substituted aromatic -amino acid is optionally substituted with one or more substituents substituents each independently selected from the group consisting of halogen, NO, OH, CN, (C)alkyl, (c)alkenyl, (c)alkynyl, (C)alkoxy, Bzl, O-Bzl, and NRR, where Rad Reach is independently H, O, or (C)alkyl; and wherein the amine nitrogen of each of amide peptide bond and the amino group of Aof formula (I) is optionally substituted with a methyl group, provided that there is at least one said methyl group; or a pharmaceutically acceptable salt thereof, and to uses thereof.