The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 27, 2008
Filed:
Jun. 17, 2004
Paul Vincent Fish, Sandwich, GB;
Michael Jonathan Fray, Sandwich, GB;
Alan Stobie, Sandwich, GB;
Florian Wakenhut, Sandwich, GB;
Gavin Alistair Whitlock, Sandwich, GB;
Mark David Andrews, Sandwich, GB;
Alan Daniel Brown, Sandwich, GB;
Mark Ian Lansdell, Sandwich, GB;
Paul Vincent Fish, Sandwich, GB;
Michael Jonathan Fray, Sandwich, GB;
Alan Stobie, Sandwich, GB;
Florian Wakenhut, Sandwich, GB;
Gavin Alistair Whitlock, Sandwich, GB;
Mark David Andrews, Sandwich, GB;
Alan Daniel Brown, Sandwich, GB;
Mark Ian Lansdell, Sandwich, GB;
Pfizer Inc., New York, NY (US);
Abstract
A compound of Formula (I) and pharmaceutically and/or veterinarily acceptable derivatives thereof, wherein Ris H, Calkyl, —C(X)Y, Ccycloalkyl, aryl, het, aryl-Calkyl or het-Calkyl, wherein the cycloalkyl, aryl or het groups are optionally substituted by at least one substituent independently selected from Calkyl, Calkoxy, OH, halo, CF, OCF, SCF, hydroxy-Calkyl, Calkoxy-Calkyl and Calkyl-S—Calkyl; Ris aryl or heteroaryl, each optionally substituted by at least one substituent independently selected from Calkyl, Calkoxy, OH, halo, CF, OCF, SCF, hydroxy-Calkyl, Calkoxy-Calkyl and Calkyl-S—Calkyl; Ris Calkyl, Ccycloalkyl, Ccycloalkyl-Calkyl, aryl, het, aryl-Calkyl or het-Calkyl, wherein the cycloalkyl, aryl or het groups are optionally substituted by at least one substituent independently selected from Calkyl, Calkoxy, OH, halo, CF, OCF, SCF, hydroxy-Calkyl, Calkoxy —Calkyl and Calkyl-S—Calkyl; X is S or O; Y is H, Calkyl, aryl, het, aryl-Calkyl or het-Calkyl; and n is 1 or 2, provided that when n is 1, m is 0 or 1 and when n is 2, m is 0, wherein if m is 0, then * represents a chiral center. The compounds of the invention exhibit activity as both serotonin and noradrenaline re-uptake inhibitors and therefore have utility in a variety of therapeutic areas, for example urinary incontinence.