The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 27, 2008
Filed:
Jun. 15, 2004
Yasuaki Ogawa, Kyoto, JP;
Takao Fujii, Tokyo, JP;
Yoko Miyamoto, Isehara, JP;
Jun Niimi, Kawasaki, JP;
Toshiyuki Ikoma, Tsukuba, JP;
Junzo Tanaka, Tsukuba, JP;
Yasuaki Ogawa, Kyoto, JP;
Takao Fujii, Tokyo, JP;
Yoko Miyamoto, Isehara, JP;
Jun Niimi, Kawasaki, JP;
Toshiyuki Ikoma, Tsukuba, JP;
Junzo Tanaka, Tsukuba, JP;
GaleniSearch, Laboratories, Kanagawa, JP;
Japan Science and Technology Agency, Saitama, JP;
Independent Administrative Institution, National Institute For Materials Science, Ibaraki, JP;
Abstract
Provided is a sustained-release microparticle preparation of a human growth hormone which combines biodegradability with sustained-release performance while avoiding the use of an organic solvent as much as possible, allows the sustained-release of a human growth hormone over 3 days or more and reduction in the initial burst release, can contain a human growth hormone at 10% or more, can quantitatively adsorb and encapsulate a human growth hormone at up to 20%, and has excellent dispersion and needle penetration properties. A process for producing the sustained-release microparticle preparation of a human growth hormone is also provided. The sustained-release microparticle preparation comprises a porous apatite derivative, a human growth hormone, and a water-soluble divalent metal compound.