The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 20, 2008
Filed:
Aug. 18, 2005
Naoyuki Shimomura, Ushiku, JP;
Manabu Sasho, Tsukuba, JP;
Akio Kayano, Kashima, JP;
Kazuhiro Yoshizawa, Kashima-gun, JP;
Masahiko Tsujii, Katori-gun, JP;
Hiroshi Kuroda, Kashima-gun, JP;
Ken Furukawa, Kashima, JP;
Naoyuki Shimomura, Ushiku, JP;
Manabu Sasho, Tsukuba, JP;
Akio Kayano, Kashima, JP;
Kazuhiro Yoshizawa, Kashima-gun, JP;
Masahiko Tsujii, Katori-gun, JP;
Hiroshi Kuroda, Kashima-gun, JP;
Ken Furukawa, Kashima, JP;
Eisai Co., Ltd., Tokyo, JP;
Abstract
In the present invention, the methods of producing a fluorinated cyclic benzamidine derivative (A), or a salt thereof, comprise the step of reacting a specific novel compound with ammonia or imide. The methods of this invention for producing a morpholine-substituted phenacyl derivative (B), or a salt thereof, comprise reaction of a specific novel compound with morpholine, reaction of the product with a halogenating reagent, and deketalization of the product. The methods of this invention for a producing cyclic benzamidine derivative (C), or a salt thereof, comprise the step of coupling compound (A), or a salt thereof, with compound (B), or a salt thereof, in the presence of an ether or a hydrocarbon. The methods of this invention for recrystallizing a cyclic benzamidine derivative (C), or a salt thereof, comprise the steps of dissolving compound (C), or the salt thereof, in a mixed solvent comprising an alcohol and water, or a mixed solvent comprising an ether and water, and after dissolution, adding additional water to precipitate crystals of compound (C), or the salt thereof.