The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 20, 2008

Filed:

Jan. 29, 2004
Applicants:

Guido Galley, Rheinfelden, DE;

Annick Goergler, Colmar, FR;

Helmut Jacobsen, Schopfheim, DE;

Eric Argirios Kitas, Aesch, CH;

Jens-uwe Peters, Grenzach-Whylen, DE;

Inventors:

Guido Galley, Rheinfelden, DE;

Annick Goergler, Colmar, FR;

Helmut Jacobsen, Schopfheim, DE;

Eric Argirios Kitas, Aesch, CH;

Jens-Uwe Peters, Grenzach-Whylen, DE;

Assignee:

Hoffmann-La Roche Inc., Nutley, NJ (US);

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 243/12 (2006.01); C07D 487/00 (2006.01); C07D 313/00 (2006.01); A61K 31/55 (2006.01); A61P 25/28 (2006.01);
U.S. Cl.
CPC ...
Abstract

The invention relates to malonamide derivatives of formula wherein each of the variables are as defined in the specification and to pharmaceutically acceptable acid addition salts thereof. The compounds are γ-secretase inhibitors. Thus, the invention also relates to pharmaceutical compositions containing these compounds and to a method of treating Alzheimer's disease by administering the compounds of the invention.


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