The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 20, 2008
Filed:
Mar. 16, 2004
Serguei Soukharev, Derwood, MD (US);
David Hammond, Laytonsville, MD (US);
Serguei Soukharev, Derwood, MD (US);
David Hammond, Laytonsville, MD (US);
The American National Red Cross, Rockville, MD (US);
Abstract
Disclosed are compounds of the formula (I): wherein R, R, R, R, and Rare selected from the group consisting of H and groups or atoms other than H, and Rand Rare halo or hydrogen; X, X, and Xare independently O or S; provided that Rand Rare not simultaneously H, when all of X, X, and Xare O; and of the formula (II) wherein R-Rare selected from the group consisting of H and groups or atoms other than H; X-Xare independently O or S; n and m are 0 or 1 but m and n cannot be 0 simultaneously; R-Rcan be H or any substituent so long as the compound of formula II upon hydrolysis provides a fluorescent compound. These compounds are useful as substrates with high specificity for organophosphatase particularly human paraoxonase and bacterial organophosphorus hydrolase. Also disclosed is a method for detecting and/or measuring the paraoxonase activity in a fluid comprising contacting the fluid with a fluorescent substrate and measuring the fluorescence of the fluorescent product formed.