The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 13, 2008

Filed:

Nov. 08, 2002
Applicants:

Annick Harel-bellan, Paris, FR;

Slimane Ait-si-ali, Villejuif, FR;

Florence Cabon-georget, Vitry sur Seine, FR;

Anne Chauchereau, Fontenay-aux-Roses, FR;

Francois Dautry, Paris, FR;

Inventors:

Annick Harel-Bellan, Paris, FR;

Slimane Ait-Si-Ali, Villejuif, FR;

Florence Cabon-Georget, Vitry sur Seine, FR;

Anne Chauchereau, Fontenay-aux-Roses, FR;

Francois Dautry, Paris, FR;

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A01N 43/04 (2006.01); A61K 31/70 (2006.01); C07H 21/04 (2006.01); C12Q 1/68 (2006.01); C12N 5/00 (2006.01);
U.S. Cl.
CPC ...
Abstract

A method of treating a disease resulting from the expression of a harmful gene is described. The method includes the step of administering a therapeutically effective amount of a pharmaceutical composition having at least one double stranded oligonucleotide including two complementary oligonucleotide sequences forming a hybrid. Each oligonucleotide sequence comprises at one of their 3' or 5′ ends one to five unpaired nucleotides forming single-strand ends extending beyond the hybrid. One of the oligonucleotide sequences is substantially complementary to a target sequence belonging to a DNA or messenger RNA molecule of a gene coding a mutated or nonmutated androgen receptor.


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