The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 13, 2008
Filed:
Oct. 30, 2003
Applicants:
DE Chao Yu, Foster City, CA (US);
Nagarajan Ramesh, Santa Clara, CA (US);
Inventors:
De Chao Yu, Foster City, CA (US);
Nagarajan Ramesh, Santa Clara, CA (US);
Assignee:
Cell Genesys, Inc., South Francisco, CA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/861 (2006.01); C12N 5/10 (2006.01); A61K 48/00 (2006.01);
U.S. Cl.
CPC ...
Abstract
Replication-competent adenoviral vectors comprising an EBV-specific transcriptional regulatory element (TRE) operably linked to a gene required for adenovirus replication are provided. By providing for transcriptional initiating regulation dependent upon transcription factors that are only active in specific, limited cell types, virus replication can be restricted to particular target cells. The modified adenovirus may be used as a vehicle for introducing new genetic capability, particularly associated with cytotoxicity for treating neoplasia.